By Ala F. Nassar

The objective of this publication is to enhance the readers' wisdom of metabolite elucidation in drug metabolism through exposing them to extensive insurance of the biotransformation of xenobiotics, ideas for picking and characterizing metabolites, FDA instructions, and case stories on how one can increase the decision-making method in structural amendment of drug applicants to lessen toxicity.

The publication includes eight chapters; it first offers an creation on biotransformation of xenobiotics, after which offers smooth ways and methods for facing metabolite characterization, utilizing instruments comparable to LC-MS, H-D alternate, sturdy isotopes LC-MS-NMR, and radiolabeled compounds. additionally, options for facing reactive intermediates in drug discovery and improvement are awarded in addition to case stories on bettering the decision-making technique within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of defense checking out of drug metabolites and why, how, and whilst to check their safety.

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