By Ala F. Nassar
The publication includes eight chapters; it first offers an creation on biotransformation of xenobiotics, after which offers smooth ways and methods for facing metabolite characterization, utilizing instruments comparable to LC-MS, H-D alternate, sturdy isotopes LC-MS-NMR, and radiolabeled compounds. additionally, options for facing reactive intermediates in drug discovery and improvement are awarded in addition to case stories on bettering the decision-making technique within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of defense checking out of drug metabolites and why, how, and whilst to check their safety.
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